The Eighth Annual PEGS conference, to be held April 30 to May 4, 2012 in Boston, MA, brings together an estimated 1,400 international decision makers in pharmaceutical, biotechnology, academia and public healthcare and focuses on the latest scientific innovations in protein engineering.

Sirona Biochem’s scientific poster, “IPGMim™, A Potential New Inducer for Difficult to Express Proteins,” will describe the use of its new inducer and how it may be effective at improving recombinant protein yields.  The poster will also include results from the latest study demonstrating the effectiveness of IPGMim™ on a recalcitrant protein and comparing the compound against a widely used inducer, IPTG. 

Additional studies are being conducted to further characterize IPGMim™ and prepare it for commercialization.

A copy of the poster will be made available on the company’s website at www.sironabiochem.com after the conference.

About Sirona Biochem Corp.
Sirona Biochem is a biotechnology company developing diabetes therapeutics, cancer vaccine antigens, skin depigmenting and anti-aging agents for cosmetic use, and biological ingredients.  The company utilizes a proprietary chemistry technique to improve pharmaceutical properties of carbohydrate-based molecules. For more information visit www.sironabiochem.com.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

For more information regarding this press release, contact:

Julie Jang
Director, Communications
Sirona Biochem Corp.
Phone:  604.282.6065
Email: jjang@sironabiochem.com

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Sirona Biochem cautions you that statements included in this press release that are not a description of historical facts may be forward-looking statements. Forward-looking statements are only predictions based upon current expectations and involve known and unknown risks and uncertainties.  You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of release of the relevant information, unless explicitly stated otherwise.  Actual results, performance or achievement could differ materially from those expressed in, or implied by, Sirona Biochem’s forward-looking statements due to the risks and uncertainties inherent in Sirona Biochem’s business including, without limitation, statements about: the progress and timing of its clinical trials; difficulties or delays in development, testing, obtaining regulatory approval, producing and marketing its products; unexpected adverse side effects or inadequate therapeutic efficacy of its products that could delay or prevent product development or commercialization; the scope and validity of patent protection for its products; competition from other pharmaceutical or biotechnology companies; and its ability to obtain additional financing to support its operations.  Sirona Biochem does not assume any obligation to update any forward-looking statements except as required by law.

In connection with closing the Private Placement, the Company has agreed to pay finders’ fees in the aggregate amount of $76,000 in cash to various finders (the “Finders”) for their efforts in sourcing purchasers for the Private Placement.  The Finders will also receive 760,000 non transferable finders’ warrants (each a “Finder’s Warrant”) representing 8% of the Units placed by each Finder.  Each Finder’s Warrant entitles the holder to purchase one common share (a “Finder’s Warrant Share”) at an exercise price of $0.18 per Finder’s Warrant Share until March 23, 2014.

All securities are subject to a four-month and one day hold period expiring on July 24, 2012.

The Company intends to use the proceeds from the Private Placement for general working capital.

About Sirona Biochem Corp.

Sirona Biochem Corp. is a biotechnology company developing diabetes therapeutics, cancer vaccine antigens, skin depigmenting and anti-aging agents for cosmetic use, and biological ingredients. The company utilizes a proprietary chemistry technique to improve pharmaceutical properties of carbohydrate-based molecules. For more information visit www.sironabiochem.com.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

For more information regarding this press release, contact:

Julie Jang Director, Communications
Sirona Biochem Corp.
Phone: 604.282.6065
Email: jjang@sironabiochem.com

“Dr. Brett Premack’s expertise in drug discovery and preclinical development will bring tremendous value in the evaluation and development of our therapeutic portfolio,” said Dr. Howard Verrico, President & CEO of Sirona Biochem. “Our chemistry platform technology gives us several program options and our ability to attract high-calibre talent like Dr. Premack enables us to efficiently advance these programs,” Dr. Verrico added.

About Dr. Brett Premack
Dr. Brett Premack is a Pharmaceutical Consultant and Technology Analyst based in San Francisco, California. He has held a number of key leadership positions in biotechnology and academia and has more than 15 years experience providing independent, strategic and technical analysis to drug discovery and pre-clinical programs in the biotechnology and pharmaceutical sectors. He is currently a technology and strategic development consultant with Qu Biologics, a clinical-stage cancer biopharmaceutical company based in Vancouver, Canada. Previously, Dr. Premack was with ChemoCentryx, Inc. as the company’s first Scientific Director after serving four years on the company’s Scientific Advisory Board. Dr. Premack was instrumental in bringing four new immunomodulatory chemokine receptor antagonist programs to the clinic (Phase I, II, III trials) for underserved inflammatory diseases. He was co-designer and developer of EnabaLink™, a collection of proprietary cell- and molecular-based functional genomics assays for evaluating immune system drug targets. As Manager, Funded Programs, he directed high-level public and private partnerships between industry, NIH, NIAID and DARPA focused on small molecule drug discovery and vaccine adjuvant programs, leading to ongoing clinical trials and testing of several radical vaccine approaches in primates. Before joining ChemoCentryx, Dr. Premack was an Assistant Professor at the University of California, Los Angeles (UCLA) Geffen School of Medicine, UCLA Molecular Biology Institute and Investigator at the Jonsson Comprehensive Cancer Center. Dr, Premack has also held previous roles at Stanford University Medical Center, Syntex Research, Roche Bioscience, Neurex Inc. (now Elan Pharmaceuticals) and Photon Technologies Inc. Dr. Premack is a former recipient of the California AIDS New Investigator Award and the Breast Cancer Novel IDEA Award.  Dr. Premack regularly speaks at major scientific conferences and is author or inventor of more than 25 published scientific papers and issued patents.

About Sirona Biochem Corp.
Sirona Biochem is a biotechnology company developing diabetes therapeutics, cancer vaccine antigens, skin depigmenting and anti-aging agents for cosmetic use, and biological ingredients.  The company utilizes a proprietary chemistry technique to improve pharmaceutical properties of carbohydrate-based molecules. For more information visit www.sironabiochem.com.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

For more information regarding this press release, contact:

Julie Jang
Director, Communications
Sirona Biochem Corp.
Phone:  604.282.6065
Email: jjang@sironabiochem.com

———————————————
Sirona Biochem cautions you that statements included in this press release that are not a description of historical facts may be forward-looking statements. Forward-looking statements are only predictions based upon current expectations and involve known and unknown risks and uncertainties.  You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of release of the relevant information, unless explicitly stated otherwise.  Actual results, performance or achievement could differ materially from those expressed in, or implied by, Sirona Biochem’s forward-looking statements due to the risks and uncertainties inherent in Sirona Biochem’s business including, without limitation, statements about: the progress and timing of its clinical trials; difficulties or delays in development, testing, obtaining regulatory approval, producing and marketing its products; unexpected adverse side effects or inadequate therapeutic efficacy of its products that could delay or prevent product development or commercialization; the scope and validity of patent protection for its products; competition from other pharmaceutical or biotechnology companies; and its ability to obtain additional financing to support its operations.  Sirona Biochem does not assume any obligation to update any forward-looking statements except as required by law.

In the study, Sirona Biochem’s inducer SBM-TFC-358 produced more protein than IPTG, a leading commercially available inducer, and was able to maintain induction over a longer period.

SBM-TFC-358 induced the synthesis of a recalcitrant protein of 13.6 kDa, known to be poorly expressed in Escherichia coli.  The study was conducted by protein engineering company PX’ Therapeutics.  In the study, SBM-TFC-358 induced more protein expression than IPTG at the same concentration of 0.1 mM. The kinetic study of induction at 37°C showed that total production (i.e. soluble and insoluble fraction) with SBM-TFC-358 was 1.7 times and 2.9 times that of IPTG at 24 and 56 hours, respectively.

“These independent results demonstrate our compound IPGMim®, when compared to IPTG, produced superior yield of a difficult to express protein – one requiring a long induction period” said Sean Cunliffe, Chief Business Officer of Sirona Biochem.  “We are excited about working with potential customers to further characterize the benefits of IPGMim® over IPTG and advance the commercialization of Sirona Biochem’s first product” added Mr. Cunliffe.

Inducers are carbohydrates which trigger recombinant protein production, which can be used in research and the manufacturing of insulin and other drugs. The quality of the inducer is key to the production process and can affect the quality and yield of the protein. Current inducers, because they are carbohydrates, are metabolically unstable, and require special handling conditions.

About Sirona Biochem Corp.
Sirona Biochem is a biotechnology company developing diabetes therapeutics, cancer vaccine antigens, skin depigmenting and anti-aging agents for cosmetic use, and biological ingredients.  The company utilizes a proprietary chemistry technique to improve pharmaceutical properties of carbohydrate-based molecules. For more information visit www.sironabiochem.com.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

For more information regarding this press release, contact:

Julie Jang
Director, Communications
Sirona Biochem Corp.
Phone:  604.282.6065
Email: jjang@sironabiochem.com

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Sirona Biochem cautions you that statements included in this press release that are not a description of historical facts may be forward-looking statements. Forward-looking statements are only predictions based upon current expectations and involve known and unknown risks and uncertainties.  You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of release of the relevant information, unless explicitly stated otherwise.  Actual results, performance or achievement could differ materially from those expressed in, or implied by, Sirona Biochem’s forward-looking statements due to the risks and uncertainties inherent in Sirona Biochem’s business including, without limitation, statements about: the progress and timing of its clinical trials; difficulties or delays in development, testing, obtaining regulatory approval, producing and marketing its products; unexpected adverse side effects or inadequate therapeutic efficacy of its products that could delay or prevent product development or commercialization; the scope and validity of patent protection for its products; competition from other pharmaceutical or biotechnology companies; and its ability to obtain additional financing to support its operations.  Sirona Biochem does not assume any obligation to update any forward-looking statements except as required by law.