
Diabetes–SGLT2 Inhibitor
Diabetes is a leading global health concern with an estimated 463 million adults afflicted with this disease. According to the International Diabetes Federation, this number is expected to grow to 700 million by 2045. Moreover, the cost of diabetes was USD 760 billion dollars a year in 2019.
Most diabetics treat their disease by controlling insulin production or regulating blood sugar through the use of medication. A diabetic patient can require up to 10 different medications at a time. Despite this large number of therapeutic options many diabetics are unable to control their disease and face significant health risks. Sirona Biochem’s SGLT2 Inhibitor SGLT2 Inhibitors work differently from other, non-insulin, diabetes therapeutics which increase insulin production in the pancreas and/or affect metabolism. SGLT2 Inhibitors act in the kidneys to reduce the re-absorption of glucose into the bloodstream. SGLT2 Inhibitors also have the potential to be strong add-on therapies to current diabetes treatments.
- SBM-TFC-039 triggers glucosuria in a dose-dependent manner
- In a glucose challenge, SBM-TFC-039 reduced blood glucose excursions by 34%
- SBM-TFC-039 reduced blood glucose in obese diabetic rats to a level of lean rats within 6 hours
- In a 28-day chronic study, SBM-TFC-039 reduced blood glucose levels in obese diabetic rats by 71%
- SBM-TFC-039 reduced blood glucose by 44% in diabetic rats compared to canagliflozin at 26%
- At 36 & 48 hours after treatment, SBM-TFC-039, at a dose of 1.0mg/kg was still effective at reducing blood glucose; canagliflozin lost its effect after 36 hours.
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